Why your antidepressant doesn’t work — it might be your DNA.
67% of depression patients try 3+ antidepressants before finding one that works. Your CYP2C19 and CYP2D6 genes determine how you metabolize SSRIs and SNRIs. Most psychiatrists prescribe blind. You can bring them the data.
ClinVar
PharmGKB
CPICNIHWhy finding the right antidepressant feels impossible
Your psychiatrist doesn’t know how your body processes SSRIs. So they guess. And you pay the price.
Years of trial and error
“After years of trying different medications” — you’ve tried Zoloft, Lexapro, Prozac. Nothing sticks. Genetic testing can narrow it down to the first prescription.
Side effects that make it worse
Weight gain, numbness, insomnia. The wrong antidepressant can make depression worse. Your CYP genes determine if a standard dose is too much for your body.
“My doctor just keeps switching”
Most psychiatrists prescribe without knowing your genotype. They try one drug, wait 6 weeks, switch. Repeat. Your DNA can end that cycle.
GeneSight costs $2,000+
Clinical pharmacogenomic tests start at $2,000 and require a doctor’s order. We deliver the same CYP gene analysis for €99, in minutes.
Find out how your body processes antidepressants.
Upload the same file you already have from 23andMe or AncestryDNA.
Three steps to the right antidepressant
Upload your DNA file
23andMe, AncestryDNA, Nebula, MyHeritage, or any VCF file. It takes 30 seconds.
We check your antidepressant genes
We analyze CYP2C19, CYP2D6, and CYP2B6 against PharmGKB and CPIC guidelines to determine your metabolizer status for each antidepressant class.
Get your depression pharma report
A clear table showing which SSRIs, SNRIs, and atypicals match your metabolism — plus a physician summary you can bring to your psychiatrist.
Your antidepressant genes are cross-referenced with PharmGKB, CPIC, and 13 other medical sources
Your antidepressant compatibility table
See exactly how your body processes each antidepressant, with actionable recommendations you can share with your psychiatrist.
Sertraline (Zoloft)
CYP2C19
Consider alternative SSRI
Escitalopram (Lexapro)
CYP2C19
Standard dosing effective
Venlafaxine (Effexor)
CYP2D6
Monitor closely, consider dose adjustment
Fluoxetine (Prozac)
CYP2D6
May need higher dose
Bupropion (Wellbutrin)
CYP2B6
Standard dosing effective
Sample antidepressant report section. Your results will be personalized to your genotype.
CYP2C19
Metabolizes most SSRIs: sertraline (Zoloft), escitalopram (Lexapro), citalopram (Celexa). Poor metabolizers may accumulate the drug, causing more side effects.
CYP2D6
Metabolizes fluoxetine (Prozac), venlafaxine (Effexor), and tricyclic antidepressants. Ultra-rapid metabolizers may clear the drug too fast for it to work.
CYP2B6
Metabolizes bupropion (Wellbutrin). Your CYP2B6 status determines whether standard dosing is effective or if adjustments are needed.
Your report includes metabolizer status, drug compatibility, and a physician-ready summary for each gene
Get your antidepressant compatibility report in 2 minutes.
Same file you already have from 23andMe or AncestryDNA.
What people discover about their antidepressants
After years of trying different medications, I finally did genetic testing and found out I have slow COMT and slow MAOA. Changed everything.
— Reddit user
My doctor just keeps switching medications. Zoloft, Lexapro, Prozac… three years and I still feel terrible.
— Reddit user
The side effects from the wrong antidepressant were worse than the depression itself. I wish I’d known sooner.
— Reddit user
67%
try 3+ antidepressants before finding one that works
672
medications covered including all major antidepressants
386
doctor-ready CPIC recommendations
2 min
from upload to your antidepressant report
Common questions
Stop guessing
which antidepressant works.
Your DNA already knows how you metabolize SSRIs and SNRIs. Give your psychiatrist the data they need.
