The health report Promethease should have been.
Promethease was acquired by MyHeritage in 2020 and has been declining ever since. SNPedia stopped updating, reports became unreliable, and users lost access to files they paid for. We built what they should have.
ClinVar
PharmGKB
StanfordNIHThe decline of Promethease
Promethease was once the go-to tool for exploring raw DNA data. Here's what happened.
SNPedia stops updating
The open-source database that powered Promethease hasn't been meaningfully updated since September 2019. Users report outdated variant classifications.
MyHeritage acquires Promethease
Promethease and SNPedia are acquired by MyHeritage. Users worry about data privacy under new corporate ownership.
Reports become unreliable
File format issues mount. 23andMe V5 format not recognized. Users report paying $15 and receiving broken or incomplete reports.
"Is the company dead?"
Multiple Reddit posts ask if Promethease is still operating. TOS changes delete user files. No customer support responds.
Users still searching for alternatives
30+ posts across Reddit communities asking for Promethease alternatives. The need hasn't disappeared — the tool has.
Same file. 100x better analysis.
Upload your 23andMe or Ancestry file — get your report in 2 minutes.
Promethease vs genome
Same raw DNA file. Dramatically different analysis.
Price
$15 (but may lose access)
€99 one-time (yours forever)
Database
SNPedia only (outdated since 2019)
15 medical sources (ClinVar, PharmGKB, GWAS, etc.)
Variants analyzed
~100K SNPs matched
Complete genetic analysis (2.6M+ markers)
AI scoring
None
AI trained on 8.8 trillion DNA sequences
Report format
"Gibberish" (Reddit quote)
Narrative, actionable, plain English
Pharmacogenomics
Basic SNPedia lookup
672 drugs, doctor-ready guidelines
Privacy
MyHeritage data policies
Zero data retention
Support
None
Active support
Database updates
Stopped 2019
Real-time from ClinVar/GWAS
The upgrade Promethease users have been waiting for.
What you were missing
Features Promethease never had — and never will.
AI variant scoring
Our AI, trained on 8.8 trillion DNA sequences, scores every genetic marker — even ones not yet in medical databases.
Medication compatibility report
672 medications checked against your drug-response genes. See how your body processes what you take, with doctor-ready dosing recommendations.
Narrative explanations
Every finding is explained in plain English. No more staring at rsID tables wondering what they mean.
Physician Summary PDF
A doctor-ready document with HGVS nomenclature, ClinVar review status, and PMID references you can bring to your appointment.
Zero data retention
Your DNA file is processed in memory and permanently deleted. We never store, share, or sell your genetic data.
15 medical databases cross-referenced
ClinVar, PharmGKB, GWAS Catalog, gnomAD, dbNSFP, AlphaMissense, PGS Catalog, ClinGen, UniProt, and more.
Switching takes 2 minutes
If you have your 23andMe or Ancestry raw file, you already have everything you need. Same file, 100x better analysis.
Upload your raw file
The same file you used with Promethease. 23andMe, AncestryDNA, MyHeritage, Nebula, or any VCF. All formats supported.
We cross-reference your DNA
We check your DNA against the same medical databases your doctor uses — ClinVar, PharmGKB, and 13 more. Not a wiki — a medical-grade analysis built by geneticists.
Get your report
Health risks, pharmacogenomics, polygenic scores, and actionable insights. In plain English, with sources you can verify.
Why people are leaving Promethease
Real frustrations from Reddit users who loved the product and watched it die.
I paid $15 for this??? All it gave me was that I might have O blood. That’s it, all on a shitty format.
— r/promethease
+12I have no idea what I’m supposed to do with this gibberish that was sent to me.
— r/genetics
+9They updated their TOS and deleted everyone’s files off the site.
— r/promethease
+10SNPedia likely hasn’t been updated at all since September 2019.
— r/genetics
+17Is the company dead / out of business?
— r/promethease
Multiple postsPromethease indicated I have a pathogenic BRCA1 variant at a magnitude of 6. Medical grade genetic testing afterwards — false positive.
— r/genetics
+122.6M
genetic markers checked
15
medical sources
672
medications covered
< 2 min
processing time
Common questions
One-time payment.
Yours forever.
No subscription. No deleted access. No gibberish. Just a health report you'll actually want to read.
